Synthetic virus-like particles from self-assembling coiled-coil lipopeptides and their use in antigen display to the immune system.
نویسندگان
چکیده
منابع مشابه
Synthetic Virus-Like Particles Target Dendritic Cell Lipid Rafts for Rapid Endocytosis Primarily but Not Exclusively by Macropinocytosis
DC employ several endocytic routes for processing antigens, driving forward adaptive immunity. Recent advances in synthetic biology have created small (20-30 nm) virus-like particles based on lipopeptides containing a virus-derived coiled coil sequence coupled to synthetic B- and T-cell epitope mimetics. These self-assembling SVLP efficiently induce adaptive immunity without requirement for adj...
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عنوان ژورنال:
- Angewandte Chemie
دوره 46 47 شماره
صفحات -
تاریخ انتشار 2007